A 25% cut in your daily caloric intake could cut your risk from some deadly ailments. A two-year Duke Health trial indicated cutting around 300 calories from your daily caloric intake reduced study participants risk for ailments such as diabetes and heart disease. A press release from Duke Health said that’s roughly the equivalent of eating six Oreo cookies. The study involved adults under age 50. While participants were asked to maintain the 25 percent daily calorie reduction, the average calorie reduction was actually about 12 percent.